Let differentiate the Exotoxins and Endotoxins in different aspects

Differences between Exotoxins and Endotoxins


  • Secreted mainly by Gram positive bacteria
  • Mainly proteinaceous in nature
  • Produces Potent toxins
  • Produce specific symptoms and act specifically on target cells i.e. Nerve, Muscle
  • Heat labile-losses toxicity at 60°C     
  • Highly antigenic
  • Toxoids can be prepared from it


  • Part of Gram negative bacterial cell wall.
  • Released only after autolysis
  • Lipopolysaccharide (LPS) in nature
  • Relatively less potent
  • Produces generalized symptoms like fever etc.
  • Heat stable
  • Weakly antigenic
  • Toxoids can’t be prepared from it

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