Differences between Exotoxins and Endotoxins
Exotoxins
- Secreted mainly by Gram positive bacteria
- Mainly proteinaceous in nature
- Produces Potent toxins
- Produce specific symptoms and act specifically on target cells i.e. Nerve, Muscle
- Heat labile-losses toxicity at 60°C
- Highly antigenic
- Toxoids can be prepared from it
Endotoxins
- Part of Gram negative bacterial cell wall.
- Released only after autolysis
- Lipopolysaccharide (LPS) in nature
- Relatively less potent
- Produces generalized symptoms like fever etc.
- Heat stable
- Weakly antigenic
- Toxoids can’t be prepared from it
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