Different inclusion bodies found in infected cells

Certain viruses produce inclusion bodies in the infected cells. Inclusion bodies are generally aggregation of virus particles in the cells infected with virus and they can be observed under the ordinary microscope.

• They are helpful for diagnosis of certain viruses. Inclusion bodies, sometimes called elementary bodies, are nuclear or cytoplasmic aggregates of stainable substances, usually proteins.
• Inclusion bodies contain very little host protein, ribosomal components or DNA/RNA fragments.
• When genes from one organism are expressed in another the resulting protein sometimes forms inclusion bodies. Some inclusions are accumulation of viral components.

Viral inclusion bodies:

Intracytoplasmic:

• Henderson-Peterson bodies in Molluscum Contagiosum
• Negri bodies in Rabies
• Guarnieri bodies(B type inclusion bodies) in Small Pox

Intranuclear:

1. Acidophilic
   1. Cowdry Type A
      • Varicella Zoster Virus
      • Herpes Simplex Virus
      • Yellow Fever Virus (Torres bodies)
   2. Cowdry Type B
      • Polio
   3. Basophilic
      • Cowdry Type B
        1. Adenovirus
      • Cytomegalovirus – Owl eye

Intranuclear and Intracytoplasmic:

1. Human Herpesvirus 6

Inclusion bodies in Red Blood Cells:

1. Developmental
   • Howell Jolly Bodies
   • Basophilic Stipplings
   • Pappenheimer bodies
   • Cabot Rings
   • Polychromatophilic Red Cells
2. Hemoglobin Precipitates
   • Heinz bodies
   • Hemoglobin H inclusions
3. Protozoal
   • Malaria
   • Babesia

For more details please download the attachment- PPT.