Types of Immunoglobulins
IgG
- Molecular weight- 180 kDa
- It can crosses placenta
- Monomer form of immunoglobulin
- Total percentage of Ab in serum is 80%
- Made up of heavy chain of ϒ
- It can fixes complement
- Function is present during secondary immune response
- Number of binding site are 2
IgM
- Molecular weight- 900 kDa
- It can’t crosses placenta
- Pentamer form of immunoglobulin
- Total percentage of Ab in serum is 6%
- Made up of heavy chain of µ
- It can fixes complement
- Function is, present during primary immune response
- Number of binding site are 10
IgA
- Molecular weight- 385 kDa
- It can’t crosses placenta
- Diamer form of immunoglobulin
- Total percentage of Ab in serum is 13% (monomer)
- Made up of heavy chain of α
- It can’t fixes complement
- Function is to provide protection on Respiratory and Urogenital surface
- Number of binding site are 4
IgD
- Molecular weight- 180 kDa
- It can’t crosses placenta
- Monomer form of immunoglobulin
- Total percentage of Ab in serum is < 1%
- Made up of heavy chain of δ
- It can’t fixes complement
- Function is act as B- cell receptor
- Number of binding site are 2
IgE
- Molecular weight- 200 kDa
- It can’t crosses placenta
- Monomer form of immunoglobulin
- Total percentage of Ab in serum is < 1%
- Made up of heavy chain of ε
- It can’t fixes complement
- Functions are to provide immunity against parasite and responsible for allergic condition
- Number of binding site are 2
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Pls elusive some adverse effects of under doase …. Befor administration…
If you administer an under dosage of drug, you will find there is no improvement and the suffering is still there.
very nice notes on immunoglobulins easy to under stand keep doing this..its very heful to us..
Thank you.