Get summarized information about the types of Immunoglobulins

Types of Immunoglobulins

IgG

  • Molecular weight- 180 kDa
  • It can crosses placenta
  • Monomer form of immunoglobulin
  • Total percentage of Ab in serum is 80%
  • Made up of heavy chain of ϒ
  • It can fixes complement
  • Function is present during secondary immune response
  • Number of binding site are 2

IgM

  • Molecular weight- 900 kDa
  • It can’t crosses placenta
  • Pentamer form of immunoglobulin
  • Total percentage of Ab in serum is 6%
  • Made up of heavy chain of µ
  • It can fixes complement
  • Function is, present during primary immune response
  • Number of binding site are 10

IgA                                              

  • Molecular weight- 385 kDa
  • It can’t crosses placenta
  • Diamer form of immunoglobulin
  • Total percentage of Ab in serum is 13% (monomer)
  • Made up of heavy chain of α
  • It can’t fixes complement
  • Function is to provide protection on Respiratory and Urogenital surface
  • Number of binding site are 4

IgD                                              

  • Molecular weight- 180 kDa
  • It can’t crosses placenta
  • Monomer form of immunoglobulin
  • Total percentage of Ab in serum is < 1%
  • Made up of heavy chain of δ
  • It can’t fixes complement
  • Function is act as B- cell receptor
  • Number of binding site are 2

IgE

  • Molecular weight- 200 kDa
  • It can’t crosses placenta
  • Monomer form of immunoglobulin
  • Total percentage of Ab in serum is < 1%
  • Made up of heavy chain of ε
  • It can’t fixes complement
  • Functions are to provide immunity against parasite and responsible for allergic condition
  • Number of binding site are 2

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